What is Glabridin?
Hundreds of functional food components were tried to find a treatment for obesity and its attached disases, and finally Licorice (Glycyrrhiza glabra) was chosen for this purpose . This component has enormous history as it was already used in ancient Egypt 4000 years ago. Licorice extract Glabridin is a newly found, unique body-fat reducing flavonoid.
It is already supported by studies that Glabridin can reduce body weight as it degrades visceral fat. It has several beneficial physiological characteristics, too.
The pharmacological effects of alcoholic Licorice extract has already been reported, e.g: chlolesterol level decreasing, anti-oxidative, anti-helicobacter pilory, kidney sterilizing etc.
-You want to get rid of kilos in a healthy way
-You experience abdominal fat accummulation
-You have high blood fat rate
-Your blood sugar value has increased
-You have a risk for high blood pressure
- You would like to live a long and healthy life
If any of the above stated facts is true for you, you have serious reason to chose Glabridin.
How does it work?
By strengthening the fat metabolism degrading processes it is able to burn the so called visceral fat. Visceral fat can be found in our inner organs, and they mean the most easily accessible, fat-stored energy of our body. Its increased multiplication can be the reason for the most diseases that are in connection with diet, and way of life. With the decrease of visceral fat, the fat of fat stores under the skin become mobilized, so the loss of abdominal cushion of flat takes place. It is promoted by studies that with the continous consumption of Glabridin the BMI (body mass index) index and physiological parameters improve.
What studies prove the various effectiveness of Glabridin?
Safety and effectiveness study:
In this study the effects of Glabridin was measured on total body fat mass and visceral fat in case of obese subjects. The researchers recruited 56 men and 28 postmenopausal women aged 40-60 years with body mass indices (BMIs) of 24-30 kg/m2.
The caloric intake of the subjects did not significantly change after 4 and 8 weeks of treatment. The subjects in the 900 mg LFO group experienced significant decreases from baseline in body weight and BMI after 4 and 8 weeks of treatment (P<0.05 for both). The changes in body weight and BMI were significantly greater in the 900 mg LFO group compared to the placebo group (P<0.005 for both). The CT scans also showed that visceral fat mass decreased significantly compared to baseline in the 900 mg LFO group only (P<0.05).
The researchers observed significant decreases in total and LDL cholesterol levels in the 900 mg LFO group (P<0.05 for both). This decrease is consistent with other studies showing that ethanolic licorice extracts reduce LDL cholesterol in patients with high cholesterol.
Antioxidant effect of polyphenolic glabridin on LDL oxidation.
This study was conducted to determine the effect of a natural polyphenolic isoflavone antioxidant (Glabridin) on low-density lipoprotein (LDL) oxidation After oral administration of licorice-root ethanol extract to healthy subjects for 6 months, the subjects' oxidative stress level as well as plasma LDL oxidation reduced by 20%. We concluded that dietary consumption of glabridin protects LDL from oxidation.
Effectiveness study on mice:
Obese mice were fed on a high-fat diet containing LFO at 0 (control), 0.5%, 1.0%, or 2.0% for 8 weeks.
Compared with mice in the control group, those in the 1% and 2% LFO groups efficiently reduced the weight of abdominal white adipose tissues and body weight gain.
A histological examination revealed that the adipocytes became smaller and the fatty degenerative state of the hepatocytes was improved in the 2% LFO group. A DNA microarray analysis of the liver showed up-regulation of those genes for beta-oxidation and down-regulation of those for fatty acid synthesis in the 2% LFO group.
These findings suggest that LFO prevented and ameliorated diet-induced obesity via the regulation of lipid metabolism-related gene expression in the liver.
A 90-day oral toxicity study in rats was conducted using an LFO concentrate solution (2.90% glabridin) It is concluded that the no-observed-adverse-effect level (NOAEL) for the LFO concentrate solution is estimated .
Glabridin effectiveness study on skin pigmentation and skin inflammation
In a comprehensive study the inhibitory effects of glabridin on melanogenesis as well as inflammation were examined on skins of guinea pigs.
Topical skin-depigmentation activities of the active component, glabridin, were examined using UVB-induced pigmented skins of brownish guinea pigs. A 0.5% glabridin solution was applied topically to the skin. Topical application of glabridin significantly reduced pigmentation induced by UVB radiation on the backs of the brownish guinea pigs.
The authors concluded that the glabridin present in Licorice roots inhibits both melanin synthesis and inflammation.
The effect of Glabridin on human bones and the skeleton of rats.
Studies were carried out in case of pre-menopausal and post-menopausal women based on their bones. At the same time the effect of Glabridin on the skeleton of rats was also studied.
The result indicated that Glabridin with or without Vitamin D can be effective to recover bone deficiency in case of post-menopausal women.
Antifungal activity of Glabridin
Glabridin, an active constituent, was found to be active against both yeast and filamentous fungi. Glabridin also showed resistance modifying activity against drug resistant mutants of Candida albicans
Effect of glabridin on learning and memory in mice.
The effect of Glabridin on memory and cognitive functions was studied in case of mice.
Result: Glabridin appears to be a promising candidate for memory improvement and it will be worthwhile to explore the potential of glabridin in the management of Alzheimer patients.
On the basis of the results it can be stated: Glabridin can decrease body weight, in minimal 300 mg/day dose, without diet, in rate of about 3 kg / year. The effect can be improved together with diet.
A DNA microarray analysis of the liver showed up-regulation of those genes for beta-oxidation and down-regulation of those for fatty acid synthesis in the 2% LFO group.
X-ray study showed that Glabridin has body weight reducing effect as it decreases fatty acid synthesis and improved oxidation of fatty acids in the liver. The studies showed that Licorice extract is a safety food component.